Wireless mind control?: New technique allows direct stimulation of neurons

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Researchers at MIT have developed a method to stimulate brain tissue using external magnetic fields and injected magnetic nanoparticles — a technique allowing direct stimulation of neurons, which could be an effective treatment for a variety of neurological diseases, without the need for implants or external connections.

The research, conducted by Polina Anikeeva, an assistant professor of materials science and engineering, graduate student Ritchie Chen, and three others, has been published in the journal Science.

Previous efforts to stimulate the brain using pulses of electricity have proven effective in reducing or eliminating tremors associated with Parkinson's disease, but the treatment has remained a last resort because it requires highly invasive implanted wires that connect to a power source outside the brain.

Anikeeva says.

In their study, the team injected magnetic iron oxide particles just 22 nanometers in diameter into the brain. When exposed to an external alternating magnetic field — which can penetrate deep inside biological tissues — these particles rapidly heat up.

The resulting local temperature increase can then lead to neural activation by triggering heat-sensitive capsaicin receptors — the same proteins that the body uses to detect both actual heat and the "heat" of spicy foods. (Capsaicin is the chemical that gives hot peppers their searing taste.) Anikeeva's team used viral gene delivery to induce the sensitivity to heat in selected neurons in the brain.

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Images show calcium ion influx into neurons as a result of magnetothermal excitation with alternating magnetic fields in the presence of magnetic nanoparticles.

The particles, which have virtually no interaction with biological tissues except when heated, tend to remain where they're placed, allowing for long-term treatment without the need for further invasive procedures.

Anikeeva says.

"Then, that region can be stimulated at will by externally applying an alternating magnetic field. The goal for us was to figure out whether we could deliver stimuli to the nervous system in a wireless and noninvasive way."

The new work has proven that the approach is feasible, but much work remains to turn this proof-of-concept into a practical method for brain research or clinical treatment.

The use of magnetic fields and injected particles has been an active area of cancer research; the thought is that this approach could destroy cancer cells by heating them. Anikeeva says.

The team developed ways to make the particles with precisely controlled sizes and shapes, in order to maximize their interaction with the applied alternating magnetic field. They also developed devices to deliver the applied magnetic field: Existing devices for cancer treatment — intended to produce much more intense heating — were far too big and energy-inefficient for this application.

The next step toward making this a practical technology for clinical use in humans Anikeeva says.

This is says Bianxiao Cui, an assistant professor of chemistry at Stanford University who was not involved in this research.

"The new method is significant in that it is relatively more easily administered and induces less brain-tissue responses as compared with electrode implantation. More importantly, the stimulation could be remotely controlled, a highly appealing feature for deep-brain stimulation."

In addition to Anikeeva and Chen, the research team also included postdoc Gabriela Romero, graduate student Michael Christiansen, and undergraduate Alan Mohr. The work was funded by the Defense Advanced Research Projects Agency, MIT's McGovern Institute for Brain Research, and the National Science Foundation.

Publication: Ritchie Chen, et al., "Wireless Magnetothermal Deep Brain Stimulation," Science, 2015; DOI: 10.1126/science.1261821